Implanted device brings movement hope to paralysis patients
Thursday, 05 November, 2020
Thanks to the implantation of a tiny device, patients with upper limb paralysis are now able to text, email and shop online.
The paper-clip-sized device 鈥 called Stentrode 鈥 was developed by researchers from , , , and .
In a trial published in the , Stentrode was implanted successfully in two patients suffering from severe paralysis due to motor neuron disease (MND) 鈥 also known amyotrophic lateral sclerosis (ALS)聽鈥 neither of whom had the complete ability to move their upper limbs. The device was able to wirelessly restore the transmission of brain impulses out of the body.
Professor Peter Mitchell, principal trial investigator and Neurointervention Service Director at The Royal Melbourne 黑料吃瓜群网, said the findings were promising and demonstrate that the device can be safely implanted and used within the patients.
鈥淭his is the first time an operation of this kind has been done, so we couldn鈥檛 guarantee there wouldn鈥檛 be problems, but in both cases the surgery has gone better than we had hoped,鈥 Professor Mitchell said.
Professor Mitchell implanted the device in the study participants through their blood vessels, next to the brain鈥檚 motor cortex, in a procedure involving a small 鈥榢eyhole鈥 incision in the neck.
鈥淭he procedure isn鈥檛 easy. In each surgery there were differences depending on the patient鈥檚 anatomy; however, in both cases the patients were able to leave the hospital only a few days later, which also demonstrates the quick recovery from the surgery,鈥 Professor Mitchell said.
Associate Professor Thomas Oxley, neurointerventionalist and CEO of research commercial partner Synchron, said this was a breakthrough moment for the field of brain鈥揷omputer interfaces.
鈥淲e are excited to report that we have delivered a fully implantable, take-home, wireless technology that does not require open brain surgery, which functions to restore freedoms for people with severe disability,鈥 said Associate Professor Oxley, who is also co-head of the Vascular Bionics Laboratory at The University of Melbourne.
The two patients used the Stentrode to control the computer-based operating system, in combination with an eye tracker for cursor navigation. This meant they did not need a mouse or keyboard. They also undertook machine-learning-assisted training to control multiple mouse click actions, including zoom and left click. The first two patients achieved an average click accuracy of 92% and 93%, respectively, and typing speeds of 14 and 20 characters per minute with predictive text disabled.
University of Melbourne Associate Professor Nicholas Opie, co-head of the Vascular Bionics Laboratory and founding Chief Technology Officer of Synchron, said the developments were exciting and the patients involved had a level of freedom restored in their lives.
鈥淥bserving the participants use the system to communicate and control a computer with their minds, independently and at home, is truly amazing,鈥 Associate Professor Opie said.
鈥淲e are thankful to work with such fantastic participants, and my colleagues and I are honoured to make a difference in their lives. I hope others are inspired by their success.
鈥淥ver the last eight years we have drawn on some of the world鈥檚 leading medical and engineering minds to create an implant that enables people with paralysis to control external equipment with the power of thought. We are pleased to report that we have achieved this."
The trial recently received a $1.48 million grant from the Australian Government to expand to hospitals in NSW and Queensland, with hopes to enrol more patients.
Although public availability of the technology is some years away, the researchers said a multidisciplinary team is working tirelessly to make the technology 鈥 capable of returning independence to complete everyday tasks 鈥 a reality.
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