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AI to predict serious health conditions — at speed


Friday, 14 July, 2023

AI to predict serious health conditions — at speed

A in artificial intelligence holds the promise of predicting a person鈥檚 risk of developing serious health conditions later in life 鈥 at the press of a button.

Abdominal aortic calcification (AAC) is a calcification that can build up within the walls of the abdominal aorta; it predicts the risk of developing cardiovascular disease events such as heart attacks and stroke. It also predicts someone鈥檚 risk of falls, fractures and late-life dementia.

by the common bone density machine scans used to detect osteoporosis; however, highly trained expert readers are needed to analyse the images in a process that can take 5鈥15 minutes per image.

Now, a multidisciplinary team of researchers have developed software that can analyse scans much, much faster: roughly 60,000 images in a single day.

Researcher and Heart Foundation Future Leader Fellow Associate Professor Joshua Lewis, from Edith Cowan University鈥檚 (ECU) , said this significant boost in efficiency will be crucial for the widespread use of AAC in research and helping people avoid developing health problems later in life.

鈥淪ince these images and automated scores can be rapidly and easily acquired at the time of bone density testing, this may lead to new approaches in the future for early cardiovascular disease detection and disease monitoring during routine clinical practice,鈥 he said.

The software was the result of an international collaboration between ECU, the University of WA, University of Minnesota, Southampton and University of Manitoba, Marcus Institute for Aging Research, and Hebrew SeniorLife Harvard Medical School.

While not the first algorithm developed to assess AAC from these images, the researchers said the study was the largest of its kind, was based on the most commonly used bone density machine models and is the first to be tested in a real-world setting using images taken as part of routine bone density testing.

It saw more than 5000 images analysed by experts and the team鈥檚 software.

After comparing the results, the expert and software arrived at the same conclusion for the extent of AAC (low, moderate or high) 80% of the time 鈥 an impressive figure given this was the first version of the software.

3% of people deemed to have high AAC levels were incorrectly diagnosed as having low levels by the software. Lewis said this was notable, as these were the individuals with the greatest extent of disease and highest risk of fatal and nonfatal cardiovascular events and all-cause mortality.

鈥淲hilst there is still to work to do to improve the software鈥檚 accuracy compared to human readings, these results are from our version 1.0 algorithm, and we already have improved the results substantially with our more recent versions,鈥 he added.

鈥淎utomated assessment of the presence and extent of AAC with similar accuracies to imaging specialists provides the possibility of large-scale screening for cardiovascular disease and other conditions 鈥 even before someone has any symptoms.

鈥淭his will allow people at risk to make the necessary lifestyle changes far earlier and put them in a better place to be healthier in their later years,鈥 Lewis concluded.

contributed funding for the project, thanks to Lewis鈥檚 2019 Future Leadership Fellowship providing support for research over a three-year period.

The findings in eBioMedicine.

Image credit: iStock.com/z1b

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