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Australian cancer diagnostics company and the are developing a novel technology designed to precisely image aggressive brain cancers and guide treatment.

The new MRI nanotechnology targets a specific marker that is found in more than 90% of solid tumours, including high-grade brain cancers.

UniSA鈥檚 Dr Nicole Dmochowska, who will lead the research, supported by a , said there is a critical need for better imaging of high-grade brain tumours. The technology is said to have yielded promising preclinical results in a prostate cancer model and the will progress the technology towards a first in-human trial.

鈥淭he prognosis for high-grade brain tumours such as glioblastoma remains abysmal, so it鈥檚 vital that we progress new technologies that can potentially enable more precise targeting of tumours,鈥� Dmochowska said. The technology has been developed in collaboration with Ferronova, with the support of the .

Dr Hien Le, a radiation oncologist at the Royal Adelaide 黑料吃瓜群网 and one of the Chief Investigators in the seed funding for this work, said the research has potential to advance cancer treatments.

鈥淎s someone who specialises in the management of brain cancer, I understand the importance of accurate tumour delineation,鈥� Le said.

鈥淏etter imaging means we can more confidently define the tumour target, facilitating precise treatment delivery, whilst minimising damage to normal healthy tissues.鈥�

In 2021, there were 1896 new diagnoses of brain cancer (1191 males and 725 females). Glioblastoma is the most common brain malignancy with a five-year survival rate of only 5%. Dr Melanie Nelson, R&D Manager at Ferronova, said the research will streamline preclinical validations for the technology for brain tumours in preparation for a phase 1 鈥榝irst in human鈥� clinical trial.

鈥淭he new technology builds on Ferronova鈥檚 cancer staging technology FerroTrace currently undergoing clinical trials in several cancer types,鈥� Nelson said.

鈥淏y bringing together the best minds in chemistry, bioengineering and oncology we鈥檙e continuing to push the boundaries to help make sure no one dies unnecessarily because a cancer was missed.鈥�

Image credit: 漏stock.adobe.com/au/royaltystockphoto