黑料吃瓜群网

International doctors have trialled a new type of CT scan to light up tiny nodules in a hormone gland and cure high blood pressure by their removal. The nodules are discovered in 1-in-20 people with high blood pressure.

128 people participated in the trial by doctors at Queen Mary University of London and Barts 黑料吃瓜群网, and Cambridge University 黑料吃瓜群网 after it was found that the participants鈥� hypertension (high blood pressure) was caused by a steroid hormone, aldosterone.

The scan found that in two-thirds of patients with elevated aldosterone secretion, this is coming from a benign nodule in just one of the adrenal glands, which can then be safely removed. The scan uses a very short-acting dose of metomidate, a radioactive dye that sticks only to the aldosterone-producing nodule.

The research solves the problem of how to detect the hormone-producing nodules without a difficult catheter study that is available in only a handful of hospitals, and often fails. The research also found that, when combined with a urine test, the scan detects a group of patients who come off all their blood pressure medicines after treatment.

The scan was said to be as accurate as the old catheter test, but quick, painless and technically successful in every patient. Until now, the catheter test was unable to predict which patients would be completely cured of hypertension by surgical removal of the gland. By contrast, the combination of a 鈥榟ot nodule鈥� on the scan and urine steroid test detected 18 of the 24 patients who achieved a normal blood pressure off all their drugs.

Professor Morris Brown, co-senior author of the study and Professor of Endocrine Hypertension at Queen Mary University of London, said, 鈥淭hese aldosterone-producing nodules are very small and easily overlooked on a regular CT scan. When they glow for a few minutes after our injection, they are revealed as the obvious cause of hypertension, which can often then be cured. Until now, 99% are never diagnosed because of the difficulty and unavailability of tests. Hopefully this is about to change.鈥�

The research, conducted on patients at Barts 黑料吃瓜群网, Cambridge University 黑料吃瓜群网, and Guy鈥檚 and St Thomas鈥檚, and Universities of Glasgow and Birmingham, was funded by the National Institute for Health and Care Research (NIHR) and Medical Research Council (MRC) partnership, Barts Charity and the British Heart Foundation.

Professor William Drake, co-senior author of the study and Professor of Clinical Endocrinology at Queen Mary University of London, said, 鈥淭his study was the result of years of hard work and collaboration between centres across the UK. Much of the 鈥榦n the ground鈥� energy and drive came from the talented research fellows who, in addition to doing this innovative work, gave selflessly of their time and energy during the national pandemic emergency. The future of research in this area is in very safe hands.鈥�

In most people with hypertension, the cause is unknown, and the condition requires life-long treatment by drugs. Previous research by the group at Queen Mary University discovered that in 5鈥�10% of people with hypertension, the cause is a gene mutation in the adrenal glands that results in excessive amounts of the steroid hormone aldosterone being produced. Aldosterone causes salt to be retained in the body, driving up the blood pressure. Patients with excessive aldosterone levels in the blood are resistant to treatment with the commonly used drugs for hypertension and at increased risk of heart attacks and strokes.

Image credit: iStockphoto.com/PeopleImages