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The has made a conditional recommendation for use of remdesivir to treat COVID-19. The antiviral drug is the first medication to be recommended as a considered treatment for hospitalised patients with the condition.

鈥淲henever possible remdesivir should be administered in the context of a randomised trial with appropriate ethical approval. Use of remdesivir for adults with moderate, severe or critical COVID-19 outside of a trial setting may be considered,鈥� the Taskforce said.

Originally developed for the treatment of Ebola, clinical trials show remdesivir may decrease time to recovery in people with moderate, severe or critical COVID-19.

Taskforce鈥檚 Executive Director, Associate Professor Julian Elliott, said while it鈥檚 early days, the findings are a significant step forward.

鈥淭his is the first information we have that a drug has a beneficial effect as a treatment for COVID-19. The preliminary data published so far from two clinical trials indicate that it can reduce the time for someone to recover from COVID-19. However, we do not yet have definitive information that remdesivir will reduce the risk of dying from the disease.

鈥淣ormally the development of clinical recommendations can take many months but the Taskforce has established processes for the rapid review of evidence using robust methods, enabling the development of this evidence-based recommendation in less than two weeks,鈥� Associate Professor Elliott said.

The Taskforce comprises 28 peak health professional bodies whose members care for people with COVID-19. Its evidence teams reviewed the preliminary results of a high-profile remdesivir trial published last week in the , adding these data to another remdesivir trial published earlier this month in .

鈥淭here are now 10 registered trials on the use of remdesivir in the treatment of COVID-19. The Taskforce looks forward to reviewing more evidence as it is published and updating our guidelines so Australian clinicians can have the support they need to provide the best possible care,鈥� Associate Professor Elliott said.

Remdesivir is not licensed for use in Australia, but the Commonwealth Government has approved exemptions to some aspects of the Therapeutic Goods Act to allow the drug to be accessed in the context of clinical trials and for compassionate use. The Taskforce understands that there is sufficient supply of remdesivir in Australia to meet current expected demand.

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Image credit: 漏stock.adobe.com/au/Mia Stendal