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It is well known that preterm birth is more likely among women who have undergone IVF than those who conceived naturally, but whether those early births were spontaneous or induced by doctors was unclear. Now, Italian scientists have found that IVF is linked with a major increase in the risk of a spontaneous preterm birth.

A new analysis of published studies found an approximate 80% increased risk of spontaneous preterm birth (both before 37 and 34 weeks) when women become pregnant via聽in vitro聽fertilisation (IVF) than through spontaneous conception. The聽聽analysis included 15 studies聽with approximately 62,000 patients and about 3800 preterm births events.

鈥淧lacental development may play a key role in the pathogenesis of spontaneous preterm birth in IVF pregnancies. We recommend ultrasound聽cervical聽screening聽in this high-risk group聽in order to apply timely preventive strategies,鈥� said lead author Dr聽Paolo Cavoretto, of the IRCCS San Raffaele 黑料吃瓜群网 in Milan, Italy. 鈥淔uture research reporting pregnancy outcomes should always emphasise etiological differentiation of preterm birth.鈥�

However, the quality of the evidence was low, suggesting further studies would be required to back up the findings.

Image credit: 漏stock.adobe.com/au/Christoph Burgstedt