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Thanks to a new Australian trial, the way in which high blood pressure is treated could change globally.

Researchers at undertook a new,聽low-dose, three-in-one pill trial to treat hypertension. The trial revealed that most patients 鈥� 70% 鈥� reached blood pressure targets with the 鈥楾riple Pill鈥�, compared to just over half receiving normal care.

With high blood pressure the leading cause of disease burden worldwide, it鈥檚 expected the findings will change guidelines globally.

The researchers tested an entirely new way of treating hypertension by giving patients three drugs, each at half dose, in a single pill for early treatment of high blood pressure. Traditionally, patients begin treatment with one drug at a very low dose, which is increased over time with additional drugs added and increased in dosage to try to reach target.

Dr Ruth Webster, of The George Institute for Global Health, said that this traditional approach required patients to regularly return to their doctor to see if they were聽meeting their targets, with multiple visits required to tailor their treatments and dosage. This was聽not only time inefficient, but聽costly. 鈥淲e also know that many doctors and patients find it too complicated and often don鈥檛 stick to the process. This new approach is much simpler and it works,鈥� she said.

Dr Webster said the Triple Pill was not only more effective than standard care, it was also safe. 鈥淚t鈥檚 estimated more than a billion people globally suffer from high blood pressure with the vast majority having poorly controlled blood pressure. Our results could help millions of people globally reduce their blood pressure and reduce their risk of heart attack or stroke.鈥�

The trial, which was conducted in Sri Lanka, enrolled 700 patients with an average age of 56 and blood pressure of 154/90 mm Hg.

Patients were randomly assigned to receive either the combination pill or usual care 鈥� their doctor鈥檚 choice of blood-pressure鈥搇owering medication. The Triple Pill consisted of the blood pressure medications telmisartan (20 mg), amlodipine (2.5 mg) and chlorthalidone (12.5 mg).

Compared with patients receiving usual care, a significantly higher proportion of patients receiving the Triple Pill achieved their target blood pressure of 140/90 or less (with lower targets of 130/80 for patients with diabetes or chronic kidney disease).

At six months, 83% of participants in the Triple Pill group were still receiving the combination pill compared to the majority of patients in the usual-care group still receiving only one and only one-third receiving two or more blood-pressure鈥搇owering drugs.

Professor Anushka Patel, Principal Investigator of the trial and Chief Scientist at The George Institute, said this was big improvement. 鈥淭he World Heart Federation has set an that by 2025 there will be a 25% reduction in blood pressure levels globally.聽The Triple Pill could be a low-cost way of helping countries around the world to meet this target.

鈥淭his study has global relevance. While the most pressing need, from the perspective of the global burden of disease, is low- and middle-income countries, it鈥檚 equally relevant in a country like Australia where we鈥檙e still achieving only 40鈥�50% control rates for high blood pressure.鈥�

The George Institute is now looking at strategies to maximise uptake of the study results. This includes examining the acceptability of the Triple Pill approach to patients and their doctors, as well as cost-effectiveness, which will be important for governments and other payers to consider.

The study, published in , was funded by the as part of the .

Image credit: 漏stock.adobe.com/au/Von Schonertagen