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From delayed diagnosis, to overprescribing, to dismissal of pain and other symptoms, there are unique challenges that women and girls face that lead to poorer health outcomes.

To address stark differences in the health outcomes for women and girls, the federal government is establishing a National Women鈥檚 Health Advisory Council. The council will be chaired by Assistant Minister for Health and Aged Care Ged Kearney and it will provide strategic advice to improve Australia鈥檚 health system for women and girls.

Diagnosis and treatment

鈥淚t is completely unacceptable that a young girl suffers ADHD symptoms without diagnosis for potentially years longer than a boy her age. Or a woman has her crippling pelvic pain repeatedly dismissed, only to find severe endometriosis,鈥澛燢earney said.

鈥淚n Australia no one should fall through the cracks when it comes to safe, high-quality and affordable health care. It鈥檚 happening too often for women and we need to find effective ways to address the problem.

鈥淲omen and girls deserve tailored and targeted health care that recognises and reflects their experiences and concerns,鈥� Kearney said.聽

The council will look at the health care offered to women and girls when it comes to menstruation, reproductive health and menopause, as well as medical consent and pain management. It will also consider medical research and health outcomes for women across a range of conditions, like heart disease, autism and cancer care.

The National Women鈥檚 Health Advisory Council will comprise some of the nation鈥檚 most eminent women鈥檚 health experts along with representatives from a mix of peak stakeholder organisations, consumer groups, and medical and professional bodies 鈥� including the voice of women with lived experience.

A key role for the new council will be to guide how the government delivers on the National Women鈥檚 Health Strategy 2020鈥�2030. Council members, who will each serve an initial three-year term, will provide advice and recommendations directly to the government, including annual reports on progress. The government may seek advice at any time outside of annual reporting.

Adverse drug reactions in women

Interestingly, recent research from the Australian National University, published in Nature Communications, reveals that women are up to 75% more likely to experience adverse reactions to prescription drugs compared to men because of a range of differences in traits between the sexes.

The lead author of the study, Dr Laura Wilson, said these adverse reactions were previously thought to be due to differences in body weight, but the reality is not that simple.

鈥淲omen are often prescribed drugs at the same dose as men despite having on average a lower body weight, meaning they often receive a higher relative dose,鈥� Wilson said.

鈥淲e analysed over two million data points, capturing over 300 traits in mice, a preclinical disease model, and it鈥檚 clear females aren鈥檛 just smaller versions of males聽鈥� meaning these drug reactions are unlikely to be alleviated by adjusting the dosage for body weight.

鈥淥ur analyses showed sex differences in many traits that cannot be explained by body weight; for example, iron levels and body temperature, morphology traits such as stored fat, and heart rate variability.鈥�

According to the researchers, we know much less about how women experience disease. 鈥淢ost biomedical research has been conducted on male cells or male animals. It has been assumed any results will apply to females as well,鈥� Wilson said.

鈥淏ut we know men and women experience disease differently, including how diseases develop, the length and severity of symptoms, and effectiveness of treatment options.鈥�

Women are often worse off as a result. 鈥淔or example, crushing chest pain is often cited as a primary symptom of heart attack. While this might be common for men, it鈥檚 a much less common symptom for women. Women are more likely to experience intense nausea,鈥� Wilson said.

鈥淥ur study could help clarify the nature of the differences in responses to certain drugs and provide a path forward to reducing drug reactions.鈥�

The research team included scientists from the University of New South Wales, as well as Liverpool John Moores University, Melio Healthcare and the European Bioinformatics Institutive in the United Kingdom.

Image credit: iStock.com/andrei_r