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A world-first study led by the University of Melbourne has revealed Kava could be an alternative treatment for hundreds of thousands of Australians who suffer from Generalised Anxiety Disorders (GAD).
The eight-week study, led by Dr Jerome Sarris from the Department of Psychiatry at the University of Melbourne, has been published in the Journal of Clinical Psychopharmacology.
Dr Sarris said GAD is a complex condition that significantly affected people鈥檚 day-to-day lives. Existing medications have a modest clinical effect and new effective options were needed for patients with anxiety.
鈥淏ased on previous work we have recognised that plant based medicines may be a viable treatment for patients with chronic anxiety. In this study we've been able to show that Kava offers a potential natural alternative for the treatment of chronic clinical anxiety. Unlike some other options it has less risk of dependency and less potential for side effects,鈥� he said.
The study also found that people鈥檚 genetic differences (polymorphisms) of certain neurobiological mechanisms called GABA transporters, may modify their response to Kava. 鈥淚f this finding is replicated, it may pave the way for simple genetic tests to determine which people may be likely to have a beneficial anxiety-reducing effect from taking Kava,鈥� Dr Sarris said.
During the study, 75 patients with clinically diagnosed GAD were given Kava, which comes from the root of the pepper plant Piper methysticum, or a placebo, and anxiety levels were regularly assessed. Results showed a significant reduction in anxiety for the Kava group compared to the placebo group at the end of the study.
In participants diagnosed with moderate to severe GAD, Kava had an even greater effect in reducing anxiety. Following the completion of the controlled phase, 26 per cent of the Kava group were classified as in remission from their symptoms compared to six per cent of the placebo group.
Kava was also well tolerated. Results showed no significant differences across the two groups for liver function which had previously been a concern for Kava鈥檚 medicinal use. In addition there were no considerable adverse reactions that could be attributed to Kava and no difference in withdrawal or addiction between the groups.
An additional novel finding of the study, recently published in Phytotherapy Research was that Kava increased women鈥檚 sex drive compared to those in the placebo group, believed to be due to the reduction of anxiety, rather than any aphrodisiac effect. Future studies confirming the genetic relationship to therapeutic response, and any libido-improving effects from Kava is now required. Dr Sarris said these significant findings are of importance to sufferers of anxiety and to the South Pacific region which relies on Kava as a major export.
The study was funded by the NHMRC and Integria Healthcare who manufacture MediHerb and Thompson鈥檚 Kava products