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A study of more than 1000 Victorian babies has shown those with hyperactive immune cells at birth, detected in their cord blood, were more likely to develop food allergies in their first year of life.
The Australian research team discovered a new pattern of immune activation at birth that was associated with an increased risk of babies developing food allergies in early life. The finding could lead to future treatments for babies and infants to prevent childhood food allergies.
The research, led by Dr Yuxia Zhang and Professor Len Harrison from the , and Associate Professor Peter Vuillermin from Barwon Health, Deakin University and the Murdoch Children's Research Institute, was published today in the journal .
Professor Harrison said the team had described a new immune 鈥榮ignature鈥� found in cord blood at birth that identified babies at risk of developing food allergies. 鈥淲e found a link between children who had hyperactive immune cells at birth and the development of allergies to milk, eggs, peanuts, wheat and other common foods in their first years of life,鈥� Professor Harrison said.
Dr Zhang said babies at risk of developing food allergies had activated immune cells at birth. 鈥淚n at-risk babies, immune cells called monocytes were activated before or during birth,鈥� Dr Zhang said. 鈥淪ignals from these cells encouraged the development of immune responses by specialised immune cells called T cells that were predisposed to cause allergic reactions to some foods.鈥�
The research used well-documented food allergy information collected by the Barwon Infant Study (BIS), a collaboration between Barwon Health, Deakin University and Murdoch Childrens Research Institute. BIS is a infant health study of more than 1000 pregnant women and their babies from the Barwon region of Victoria, looking at immunity and allergy as well as respiratory, cardiovascular and neurological development.
Associate Professor Vuillermin, a paediatrician who leads the BIS, said childhood food allergies had become very common in Australia.
鈥淭here has been a three-fold increase in hospital presentations due to food allergy over recent decades, and most of this increase has been among children under five years of age,鈥� Associate Professor Vuillermin said. 鈥淚n fact up to one in every 10 babies in Melbourne develop food allergy during the first year of life.
鈥淲e don鈥檛 know why the increase in food allergy has occurred. The important thing about this study is that we鈥檝e shown the immune systems of babies who develop food allergy are in a sense 鈥榩rimed鈥� for allergic disease by the time they are born,鈥� Associate Professor Vuillermin said.
Professor Harrison said one of the next steps for the research team would be to identify why these babies have hyperactive immune cells.
鈥淎re the immune cells inherently activated because of the baby鈥檚 genes or do they become activated at the time of birth or earlier in pregnancy, and how?鈥� Professor Harrison said.
鈥淭his study really emphasises how critical it is to look at pregnancy and early life to really understand why chronic immune and inflammatory disorders such as allergies develop in childhood and later.鈥�
The research was funded by the Australian National Health and Medical Research Council, Walter and Eliza Hall Institute Catalyst Fund and the Victorian State Government Operational Infrastructure Support Program and the Australian Food Allergy Foundation